The Effect of Topical Aliskiren on Ocular Hypertension Induced by Water Loading in Rabbits

The aim of this work was to assess the effect of topical instillation of aliskiren on the ocular hypertension induced by water loading in rabbits. The effect of three different concentrations of aliskiren (7.5, 15 and 30mg/ml) on the intraocular pressure rise produced by oral administration of tap water (60 ml/kg) was tested in groups of six rabbits each. When applied at the utilized concentrations studied, topical aliskiren was found to decrease the intraocular pressure rise after water loading within a certain intervals of time. This effect was found to be dose-dependent when compared with that reported in control group at the same corresponding time. Although aliskiren, and probably other rennin inhibitors, may be useful in the management of ocular hypertension, the data obtained suggest that these drugs may have complex actions on aqueous humor dynamics; therefore further studies in animal models of glaucoma should be carried out before their clinical evaluation in humans.